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Human evidence - Phase 3 TRANSCEND-T2D-1 (Eli Lilly, March 19, 2026) 537 adults with type 2 diabetes, randomized 1:1:1:1 to retatrutide 4, 9, or 12 mg or placebo
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However, an overactive estrobolome, particularly if secondary to dysbiosis (an imbalance in gut microbiota) or the overgrowth of beta-glucuronidase-producing bacteria like Bacteroides and Clostridia, can lead to excessive estrogen reabsorption
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