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In animal studies, resmetirom increases the expression of genes involved in fatty acid oxidation ( CPT1A , ACOX1 ), mitochondrial biogenesis ( PPARGC1A ), and cholesterol catabolism ( CYP7A1 ), while reducing levels of lipogenic targets ( SREBP-1c , FASN ) [1921]
I., Gazda, C
[1] The FDA label for tirzepatide includes warnings about acute gallbladder disease, as GLP-1 receptor agonists have been associated with an increased risk of cholelithiasis or cholecystitis
Role of oxidized low density lipoprotein in atherogenesis
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