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In addition, it has been observed that MTX can increase intestinal permeability which has been linked to hepatic inflammation, abnormal liver histological changes such as fibrosis, cirrhosis, and apoptosis of liver cells, and higher levels of hepatic transaminases (Cao et al

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Administration of Bifidobacterium breve improves the brain function of A1-42-treated mice via the modulation of the gut microbiome