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PMID: 20190196 Reported Macrocycle stability Lactam-bridged backbone confers proteolytic stability The side-chaintoside-chain lactam bridge between Asp(2) and Lys(7) is reported in macrocyclization-strategies reviews to confer proteolytic stability relative to linear -MSH and to constrain the receptor-binding pharmacophore (the conserved His-Phe-Arg-Trp / HFRW core, with D-Phe at position 4 of the cycle in PT-141)
C-EL performed the statistical analysis
Applicable Procedure Code: J1602
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This article covers the exact temperature thresholds that trigger degradation, the refrigeration protocol for both powder and reconstituted forms, and what happens when storage protocols fail
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