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Back in 2025, researchers from the ATTAIN-1 trial found that taking orforglipron for 72 weeks was associated with significant benefits in patients with weight-related medical problems without diabetes

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modelling suggests enough weight loss via GLP-1 therapy could prevent ~1 % of cancers over 25 years, plus cardiovascular benefits

Medical costs associated with obesity exceed $250 billion annually, according to the Institute for Clinical and Economic Review (ICER)