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Conversely, aged cardiovascular systems might respond differently to the peptides multiple mechanisms, and these differences remain unstudied

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Moreover, S100A8/S100A9 complex binds to endothelial cells via the S100A9 subunit interacting chiefly with heparin and heparan sulfate proteoglycans (125), contributing to the immobilization of the myeloid cell-derived S100A8/S100A9 complex on endothelium in human inflammatory diseases

They launch a localized inflammatory response designed to contain and neutralize the perceived threat